Intensive Care Medicine Experimental (ICMx) is an exciting new journal dedicated to basic, translational and experimental research relating to all facets of critical illness. This can range from in silico and in vitro studies, through to in vivo and ex vivo investigations in both laboratory animals and patients. A prestigious board of committed Senior Editors and Editors underlines our strong belief in this initiative. We encourage high-quality submissions with the aim of being the focal point for publishing experimental research in the specialty, be it physiological, biochemical or biological/immunological.