BMC Methods is an open-access, peer-reviewed journal that focuses on publishing lab protocols and methodology papers in the natural sciences, including biology, chemistry, physics, computational and biomedical sciences.  The journal serves as a platform for researchers to disseminate experimental procedures, novel techniques, and innovative methodologies, promoting reproducibility, transparency, and the advancement of scientific methods.  The journal considers manuscripts in the following broad subject-specific sections: Molecular biology Genomic and transcriptomic Proteomics Metabolomics and lipidomics Microscopy and imaging Genome editing Model systems and organisms Computational biology and bioinformatics Structural biology Plant biology, ecology and evolution Tissue engineering and regenerative medicine We particularly welcome lab protocols that have a strong emphasis on providing comprehensive explanations for each step and robust supporting data to facilitate the wider adoption of the described methods.  Submissions should address relevant questions within each discipline.  Authors are encouraged to demonstrate their method's performance compared to existing approaches. BMC Methods also considers manuscripts that explore the theoretical foundations of methods and propose enhancements or optimizations. For lab protocols, we welcome detailed step-by-step procedures. Please note that study protocols are not within the journal's scope but are considered in the main medical and veterinary subject-specific BMC Series journals. Articles on the methodology of epidemiological research, clinical trials and meta-analysis/systematic review, and empirical studies of the associations between choice of methodology and study outcomes are considered at BMC Medical Research Methodology. As a BMC Series journal, BMC Methods does not make editorial decisions based on the perceived interest or potential impact of a study. Manuscripts are considered for publication if they are scientifically valid. For methodology and protocol articles, this includes having a clearly defined and sound research question, appropriate methodology and analysis, and adherence to community-agreed standards relevant to the field. .