TY  - BOOK
AU  - Gotta,Monica
AU  - Meraldi,Patrick
ED  - SpringerLink (Online service)
TI  - Cell Division Machinery and Disease
T2  - Advances in Experimental Medicine and Biology,
SN  - 9783319571270
AV  - QH573-671 
U1  - 571.84 23
PY  - 2017///
CY  - Cham
PB  - Springer International Publishing, Imprint: Springer
KW  - Cell cycle
KW  - Cell physiology
KW  - Cancer research
KW  - Cell Cycle Analysis
KW  - Cell Physiology
KW  - Cancer Research
N1  - 1.Meiotic divisions: no place for gender equality -- 2.Consequences of centrosome dysfunction during brain development -- 3.Dividing with extra centrosomes: a double edged sword for cancer cells -- 4.Kinetochore malfunction in human pathologies -- 5.The elephant in the room: the role of microtubules in cancer -- 6.Clinical development of anti-mitotic drugs in cancer -- 7.Mitotic dysfunction associated with aging hallmarks -- 8.Unbalanced Growth, Senescence and Aging -- 9.The spindle orientation machinery beyond mitosis: when cell specialization demands polarization; Available to subscribing member institutions only. Доступно лише організаціям членам підписки
N2  - This book critically evaluates the causal link between cell division machinery and disease. Further, it identifies key open questions in the field and the means for exploring them. Throughout the various chapters, internationally known contributors present the evidence for and against a causal link between key elements of the cell division machinery and diseases such as cancer, neuropathologies, aging, and infertility. A more clinically oriented chapter further discusses the current and future applications of anti-mitotic drugs in these diseases. Cell Division Machinery and Disease is essential reading for graduate or advanced graduate students, researchers or scientists working on cell division as well as clinicians interested in the molecular mechanisms of the discussed diseases
UR  - https://doi.org/10.1007/978-3-319-57127-0
ER  -