TY - BOOK AU - Engin,Ayse Basak AU - Engin,Atilla ED - SpringerLink (Online service) TI - Obesity and Lipotoxicity T2 - Advances in Experimental Medicine and Biology, SN - 9783319483825 AV - QH345 U1 - 572 23 PY - 2017/// CY - Cham PB - Springer International Publishing, Imprint: Springer KW - Biochemistry KW - Pharmacology KW - Endocrinology  KW - Biochemistry, general KW - Pharmacology/Toxicology KW - Endocrinology N1 - Available to subscribing member institutions only. Доступно лише організаціям членам підписки N2 - Due to the resultant health consequences and considerable increase in prevalence, obesity has become a major worldwide health problem. “Obesity and Lipotoxicity” is a comprehensive review of the recent researches to provide a better understanding of the lipotoxicity-related mechanisms of obesity and the potential for the development of new treatment strategies. This book overviews the biochemical pathways leading to obesity-related metabolic disorders that occur subsequent to lipotoxicity. Chapters examine the deleterious effects of nutrient excess at molecular level including the cellular and molecular aspects of breast cancer, resistance to leptin, insulin, adiponectin, and interconnection between the circadian clock and metabolic pathways during high-fat feeding. “Lipotoxicity and Obesity” will be a useful resource for clinicians and basic science researchers, such as biochemists, toxicologists, immunologists, nutritionists, adult and pediatric endocrinologists, cardiologists, as well as students who are thought in this field UR - https://doi.org/10.1007/978-3-319-48382-5 ER -