TY  - BOOK
AU  - Tran,Lang
AU  - Bañares,Miguel A.
AU  - Rallo,Robert
ED  - SpringerLink (Online service)
TI  - Modelling the Toxicity of Nanoparticles
T2  - Advances in Experimental Medicine and Biology,
SN  - 9783319477541
AV  - RM1-950 
U1  - 615 23
PY  - 2017///
CY  - Cham
PB  - Springer International Publishing, Imprint: Springer
KW  - Pharmacology
KW  - Nanotechnology
KW  - Systems biology
KW  - Pharmacology/Toxicology
KW  - Systems Biology
N1  - Engineered Nanoparticles – Their physico-chemical characteristics and how to measure them -- Measurement  -- The Life-Cycle of Engineered Nanoparticles -- From Dose to Response – In vivo Nanoparticle Processing and Potential Toxicity -- From Dose to Response – Literature review od (Q)SAR Modelling of Nanomaterial Toxicity -- Systems biology to support nanomaterial grouping -- Multiscale modelling of bionano interface -- Biological Surface Adsorption Index of Nanomaterials - Modeling Surface Interactions of Nanomaterials with Biomolecules -- Case study I - An integrated data-driven strategy for safe-by-design nanoparticles: The FP7 MODERN Project -- Case study II - Compilation of Data and Modeling of Nanoparticle Interactions and Toxicity and in the European NanoPUZZLES Project -- Case study III – The construction of a nanotoxicity database: the MOD-ENP-TOX experience; Available to subscribing member institutions only. Доступно лише організаціям членам підписки
N2  - In today’s nanotechnology and pharmaceutical research, alternative toxicology testing methods are crucial for ethically and commercially sound practice. This book provides practical guidelines on how to develop and validate quantitative nanostructure-toxicity relationship (QNTR) models, which are ideal for rapidly exploring the effects of a large number of variables in complex scenarios. Through contributions by academic, industrial, and governmental experts, Modelling the Toxicity of Nanoparticles delivers clear instruction on these methods and their integration and use in risk assessment. Specific topics include the physico-chemical characteristics of engineered nanoparticles, nanoparticle interactions, in vivo nanoparticle processing, and more. A much-needed practical guide, Modelling the Toxicity of Nanoparticles is a key text for researchers as well as government and industry regulators
UR  - https://doi.org/10.1007/978-3-319-47754-1
ER  -