TY - BOOK AU - Juan Colás,José ED - SpringerLink (Online service) TI - Dual-Mode Electro-photonic Silicon Biosensors T2 - Springer Theses, Recognizing Outstanding Ph.D. Research, SN - 9783319605012 AV - QH505 U1 - 571.4 23 PY - 2017/// CY - Cham PB - Springer International Publishing, Imprint: Springer KW - Biophysics KW - Biological physics KW - Optical materials KW - Electronic materials KW - Electrochemistry KW - Physical measurements KW - Measurement    KW - Surfaces (Physics) KW - Interfaces (Physical sciences) KW - Thin films KW - Biological and Medical Physics, Biophysics KW - Optical and Electronic Materials KW - Measurement Science and Instrumentation KW - Surface and Interface Science, Thin Films N1 - Introduction -- Fundamentals of Label-Free Biosensing -- Fabrication and Experimental Techniques -- The Electro-photonic Silicon Biosensor -- Study and Application of Electrografted Layers of Diazonium Ions -- Tailoring Light-matter Interaction for Quantification of Biological and Molecular Layers -- Conclusions and Outlook; Available to subscribing member institutions only. Доступно лише організаціям членам підписки N2 - This highly interdisciplinary thesis reports ontwo innovative photonic biosensors that combine multiple simultaneous measurements to provide unique insights into the activity and structure of surface immobilized biological molecules. In addition, it presents a new silicon photonic biosensor that exploits two cascaded resonant sensors to provide two independent measurements of a biological layer immobilized on the surface. By combining these two measurements, it is possible to unambiguously quantify the density and thickness of the molecular layer; here, the approach’s ability to study molecular conformation and conformational changes in real timeis demonstrated. The electrophotonic biosensor integrates silicon photonics with electrochemistry into a single technology. This multi-modal biosensor provides a number of unique capabilities that extend the functionality of conventional silicon photonics. For example, by combining the complementary information revealed by simultaneous electrochemical and photonic measurements, it is possible to provide unique insights into on-surface electrochemical processes. Furthermore, the ability to create electrochemical reactions directly on the silicon surface provides a novel approach for engineering the chemical functionality of the photonic sensors. The electrophotonic biosensor thus represents a critical advance towards the development of very high-density photonic sensor arrays for multiplexed diagnostics UR - https://doi.org/10.1007/978-3-319-60501-2 ER -