05059nam a22006135i 4500 978-3-319-45433-7 DE-He213 20210118151540.0 cr nn 008mamaa 161130s2017 gw | s |||| 0|eng d 9783319454337 978-3-319-45433-7 10.1007/978-3-319-45433-7 doi R857.M3 TGM bicssc TEC021000 bisacsh TGM thema TCB thema 620.11 23 The Immune Response to Implanted Materials and Devices [electronic resource] : The Impact of the Immune System on the Success of an Implant / edited by Bruna Corradetti. 1st ed. 2017. Cham : Springer International Publishing : Imprint: Springer, 2017. XVIII, 241 p. 25 illus., 20 illus. in color. online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Host response to implanted materials and devices - overview -- Innate and acquired immunity: umoral and cellular components (Protein adsorption, cell recruitment, tissue response) -- Acute/Chronic inflammation, foreign body reaction - implications -- Macrophages: from immune response to tissue restoration -- Host response to cell-grafted biomaterials -- Host response to therapeutic nanoparticles -- Host response to synthetic versus natural biomaterials (The effects of the composition, structure on function, stability, and final outcome) -- Biomimicry at the cell-material interface to mitigate the immune reaction -- Bioactive materials design for immunomodulation - exploiting the patient’s own body machinery to achieve functional tissue restoration -- Host response to materials for orthopaedic applications: current approaches and future perspectives -- Methods to activate cellular immunity or determine immune evasion. This book provides a comprehensive overview of the cascade of events activated in the body following the implant of biomaterials and devices. It is one of the first books to shed light on the role of the host immune response on therapeutic efficacy of an implant, and reviews the state-of-the-art for both basic science and medical applications. The text examines advantages and disadvantages of the use of synthetic versus natural biomaterials. Particular emphasis is placed on the role of biomimicry in the development of smart strategies able to modulate infiltrating immune cells, thus reducing side effects (such as acute and chronic inflammation, fibrosis and/or implant rejection) and improving the therapeutic outcome (healing, tissue restoration). Current cutting-edge approaches in tissue engineering, regenerative medicine, and nanomedicine offer the latest insights into the role immunomodulation plays in improving tolerance during cells and tissue transplant, in the treatment of orthopaedic, pancreatic, and hepatic diseases.The Immune Response to Implanted Materials and Devices is intended for an audience of graduate students and professional researchers in both academia and industry interested in the development of smart strategies, which are able to exploit the self-healing properties of the body and achieve functional tissue restoration. Biomaterials. Regenerative medicine. Tissue engineering. Immunology. Biomedical engineering. Biomaterials. http://scigraph.springernature.com/things/product-market-codes/Z13000 Regenerative Medicine/Tissue Engineering. http://scigraph.springernature.com/things/product-market-codes/L16080 Immunology. http://scigraph.springernature.com/things/product-market-codes/B14000 Biomedical Engineering and Bioengineering. http://scigraph.springernature.com/things/product-market-codes/T2700X Corradetti, Bruna. editor. edt http://id.loc.gov/vocabulary/relators/edt SpringerLink (Online service) Springer eBooks Printed edition: 9783319454313 Printed edition: 9783319454320 Printed edition: 9783319832937 https://doi.org/10.1007/978-3-319-45433-7 ZDB-2-CMS 452729 452729 EB Available to subscribing member institutions only. Доступно лише організаціям членам підписки. Online access from local network of NaUOA. Online access with authorization at https://link.springer.com/ Онлайн-доступ з локальної мережі НаУОА. Онлайн доступ з авторизацією на https://link.springer.com/