TY  - BOOK
AU  - Hangartner,Lars
AU  - Burton,Dennis R.
ED  - SpringerLink (Online service)
TI  - Vaccination Strategies Against Highly Variable Pathogens
T2  - Current Topics in Microbiology and Immunology,
SN  - 9783030580049
AV  - RM281 
U1  - 615.372 23
PY  - 2020///
CY  - Cham
PB  - Springer International Publishing, Imprint: Springer
KW  - Vaccines
KW  - Infectious diseases
KW  - Virology
KW  - Immunology
KW  - Human physiology
KW  - Vaccine
KW  - Infectious Diseases
KW  - Human Physiology
N1  - Successful Vaccines -- Immunogenicity and Immunodominance in Antibody Responses -- Immunogen Design -- Adjuvants -- Tools to screen vaccines -- Targeting glycans on human pathogens for vaccine design -- BnAbs and highly antigenically variable pathogens
N2  - Vaccines against antigenically stable pathogens, or pathogens that only exist in a limited number of serotypes, have been very successful in the past and have drastically decreased the incidence and lethality of many diseases. However, when it comes to highly variable pathogens or viruses that exist in multiple serotypes, the traditional methods for vaccine development have reached their limits. This volume highlights the development of vaccines against such challenging pathogens. Novel approaches for immunogen design, including structure-guided vaccine development and vaccines targeting glycans, as well as adjuvants and animal models used for testing possible vaccine candidates are outlined and discussed in detail. Given its scope, the book will appeal to scientists in the fields of infectious diseases, microbiology and medicine.
UR  - https://doi.org/10.1007/978-3-030-58004-9
ER  -