The European Journal of Nutrition publishes original papers, reviews, and short communications in the nutritional sciences. The manuscripts submitted to the European Journal of Nutrition should have their major focus on the impact of nutrients and non-nutrients on immunology and inflammation, gene expression, metabolism, chronic diseases, or carcinogenesis, or a major focus on epidemiology, including intervention studies with healthy subjects and with patients, biofunctionality of food and food components, or the impact of diet on the environment. Letters to the editors may be submitted. Letters are expected to provide substantive comments on papers published in the European Journal of Nutrition. Both the letter and a reply, if appropriate, are published together whenever possible. Papers with a major focus on traditional medicine or food technology will not be accepted. Nor will case studies be accepted. European Journal of Nutrition will consider animal studies only if they are sufficiently justified, i.e. the work in question could not have been done in human volunteers. Immediate reject: Submitted manuscripts can be rejected without detailed comments after initial review by an editor if the manuscripts are considered inappropriate or of insufficient importance for publication in the European Journal of Nutrition. Submitted manuscripts will not be reviewed if they fail to match the aims and scope of the European Journal of Nutrition, or if they do not conform to standard English usage and do not meet the formatting requirements. Supplemental issues: Symposia or workshop articles may be published as supplemental issues in the European Journal of Nutrition and are funded by their sponsors at a special rate. The European Journal of Nutrition welcomes queries about the publication of supplemental issues.