Genome Instability & Disease (GIAD) publishes high-quality, peer-reviewed original research papers, short communications, and review articles on the molecular mechanisms underlying genome stability maintenance and genome instability-associated human diseases and therapeutic applications. In particular, GIAD publishes novel data regarding the regulatory mechanisms of genome stability, including epigenetic and post-translational modifications, and the DNA damage response and its association with the inheritance of mutations that contribute to genetic disorders, neurodegenerative diseases, cancer, and ageing. Topics may include, but are not limited to: §  Cell cycle checkpoints §  DNA damage response §  Post-translational modifications §  Epigenetic regulation §  Radio/chemotherapeutic sensitization §  Genome stability genes as a therapeutic target §  Genome instability-associated diseases §  Neurodegenerative diseases §  DNA damage-based therapy and drug discovery GIAD publishes one volume per year, consisting of six regular issues with a minimum of five original articles per issue. All submissions undergo a double-blind peer review process.